In Vitro Inhibition Effects of 2-Amino Thiazole Derivatives on Lactoperoxidase Enzyme Activity

Lactoperoxidase (LPO E.C. 1.11.1.7) is a member of the peroxidase family and an important glycoprotein containing heme group in its structure showing antimicrobial effect on disease causing microorganisms digestive system newborn babies. Thiazoles are simplest members heterocyclic compounds nitrogen sulfur atoms their structure. Many active pharmaceutical substances such as vitamin B1, penicillin, those obtained by synthesis, contain thiazole ring. It desirable to evaluate biological activities derivatives, antiprotozoal antibacterial, antifungal, antituberculosis, anthelmintic, with emphasis potential medical applications. The aim this study was determine vitro inhibition profiles 2-amino derivatives against bovine LPO enzyme. In it determined that all amino inhibited enzyme competitively. When results were compared each other, 2-Amino-4-(4-chlorophenyl) compound showed best Ki value 250±100 nM.